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Updated: Jul 1, 2025

Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures
Published on: March 28, 2018
Development has the answer: Unraveling psychiatric disorders via thalamocortical organoids
Eduardo Leyva-Díaz1, Emily S Wilson1, Guillermina López-Bendito1
1Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Juan de Alicante, Alicante, Spain.
Abstract:
Dissecting the role of the thalamus in neuropsychiatric disorders requires new models to analyze complex genetic interactions. In this issue of Cell Stem Cell, Shin et al. use patient-derived thalamocortical organoids to investigate 22q11.2 microdeletion impact on thalamic development, revealing significant transcriptional dysregulation linked to psychiatric disorders.
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