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RNA interference-based therapies for atherosclerosis: Recent advances and future prospects
Negin Parsamanesh1, Mohadeseh Poudineh2, Haleh Siami3
1Department of Genetics and Molecular Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Progress in Molecular Biology and Translational Science
|March 8, 2024
Summary
RNA interference (RNAi) therapies, including microRNAs and small interfering RNAs (siRNAs), show promise for cardiovascular disease (CVD). Challenges in delivery, stability, and toxicity must be addressed for effective clinical application.
Area of Science:
- Biomedical Science
- Molecular Biology
- Cardiovascular Research
Background:
- Atherosclerosis is a chronic arterial disease characterized by atheroma buildup.
- RNA-based therapies offer new treatment avenues for cardiovascular disease (CVD).
Approach:
- This review details the current landscape of RNA interference (RNAi) therapies.
- Focuses on microRNAs and small interfering RNAs (siRNAs) for gene regulation.
Key Points:
- RNAi therapies target RNA molecules to modulate gene expression and protein production.
- Key challenges include delivery, stability, immunogenicity, and off-target toxicity.
- Overcoming these obstacles is crucial for developing effective RNAi medications.
Conclusions:
- RNA interference (RNAi) therapies represent a rapidly evolving field with significant potential for treating atherosclerosis and other cardiovascular diseases.
- Further research and development are necessary to overcome existing limitations and translate these therapies into clinical practice.
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