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Application of RNA-based therapeutics in glioma: A review
Mehdi Sanati1, Amir R Afshari2, Seyed Sajad Ahmadi3
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Birjand University of Medical Sciences, Birjand, Iran; Experimental and Animal Study Center, Birjand University of Medical Sciences, Birjand, Iran.
Abstract:
Despite the extensive advancements made in the field of cancer therapy, the outlook of individuals suffering from glioblastoma multiforme remains highly detrimental. The absence of specific treatments for cancerous cells significantly hinders the effectiveness of conventional anticancer techniques. Multiple research studies have demonstrated that the suppression of specific genes or the augmentation of therapeutic proteins through RNA-based therapeutics may represent a valuable approach when combined with chemotherapy or immunotherapy. In recent years, there has been a significant increase in the application of RNA therapeutics in conjunction with chemotherapy and immunotherapy. This emerging field has become a prominent area of research for advancing various types of cancer treatments. The present investigation provides an in-depth overview of the classification and application of RNA therapy, focusing on the mechanisms of RNA antitumor treatment and the current status of clinical studies on RNA drugs.
Insights
RNA therapeutics offer a promising approach to combat glioblastoma multiforme by targeting specific genes. This strategy enhances conventional treatments like chemotherapy and immunotherapy for better cancer outcomes.
Area of Science:
- Oncology
- Molecular Biology
- Biotechnology
Background:
- Glioblastoma multiforme (GBM) presents a poor prognosis due to a lack of targeted therapies.
- Conventional cancer treatments face limitations in specifically targeting cancerous cells.
- RNA-based therapeutics are emerging as a novel strategy to overcome these limitations.
Approach:
- This review explores the classification and application of RNA therapeutics in cancer treatment.
- It details the mechanisms by which RNA-based drugs exert antitumor effects.
- The current clinical landscape of RNA drugs for cancer is examined.
Key Points:
- RNA therapeutics can be used to suppress specific genes or enhance therapeutic protein levels.
- Combining RNA-based treatments with chemotherapy or immunotherapy shows significant potential.
- This approach aims to improve the efficacy of existing cancer therapies.
Conclusions:
- RNA therapeutics represent a significant advancement in oncology, particularly for difficult-to-treat cancers like GBM.
- The integration of RNA-based strategies with conventional treatments is a rapidly growing research area.
- Further clinical studies are crucial to fully realize the potential of RNA drugs in cancer therapy.
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