Disease activity trajectories from childhood to adulthood in the population-based Nordic juvenile idiopathic arthritis cohort
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Four long-term juvenile idiopathic arthritis (JIA) disease activity trajectories were identified. Patient
Area Of Science
- Pediatric Rheumatology
- Longitudinal Disease Trajectory Analysis
- Juvenile Idiopathic Arthritis (JIA)
Background
- Juvenile idiopathic arthritis (JIA) requires understanding long-term disease activity.
- The clinical Juvenile Arthritis Disease Activity Score (cJADAS10) is a key metric.
- Identifying distinct disease trajectories is crucial for patient management.
Purpose Of The Study
- To identify long-term disease activity trajectories in JIA patients from childhood to adulthood.
- To evaluate the contribution of cJADAS10 components to disease activity.
- To explore factors associated with active disease at 18-year follow-up.
Main Methods
- Utilized a population-based Nordic JIA cohort with 18-year follow-up.
- Employed discrete mixture models for longitudinal clustering of cJADAS10 and its components.
- Assessed patient's global assessment of well-being (PaGA) using hierarchical clustering and correlation analysis.
Main Results
- Identified four distinct cJADAS10-based disease activity trajectories in 427 JIA patients.
- Observed significant increases in PaGA and physician's global assessment (PhGA) in one trajectory group, without increased joint counts.
- Higher PaGA scores correlated with unfavorable patient-reported outcomes, indicating its significant impact.
Conclusions
- Identified distinct long-term disease activity trajectories in JIA.
- Patient's global assessment (PaGA) emerged as the primary driver of disease activity into adulthood.
- Emphasized the need for strategies to achieve patient- and physician-perceived inactive disease.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
• Symptom Review: Chronic symptoms such as persistent cough, sputum production, shortness of breath (dyspnea), and episodes of exacerbation are...
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Intermittent Asthma:
Symptoms occur fewer than twice a week.
Night-time awakenings due to asthma occur fewer than twice a...
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...