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Updated: Jul 1, 2025
FIBS-enabled Noninvasive Metabolic Profiling
Published on: February 3, 2014
Self-powered optical fiber biosensor integrated with enzymes for non-invasive glucose sensing
Xingyue Wen1, Xinghua Yang1, Zhongxuan Ge1
1Key Laboratory of Photonic Materials and Devices Physics for Oceanic Applications, Ministry of Industry and Information Technology of China, College of Physics and Optoelectronic Engineering, Harbin Engineering University, Harbin, 150001, China; Key Laboratory of In-Fiber Integrated Optics of Ministry of Education, College of Physics and Optoelectronic Engineering, Harbin Engineering University, Harbin, 150001, China.
A new non-invasive tear glucose biosensor uses an optical fiber and enzymes for self-powered detection. This innovative device offers a comfortable and effective method for monitoring blood glucose levels in diabetic patients.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Materials Science
Background:
- Frequent blood glucose monitoring is essential for diabetic patient management.
- Current invasive methods cause discomfort and patient non-compliance.
- Development of non-invasive glucose detection methods is highly desirable.
Purpose of the Study:
- To develop a novel non-invasive tear glucose biosensor.
- To create a self-powered photoelectrochemical probe for glucose detection.
- To offer a comfortable and efficient alternative to invasive blood glucose monitoring.
Main Methods:
- Designed and prepared a photoelectrochemical probe using an optical fiber and glucose oxidase.
- Integrated nanomaterials onto the optical fiber for enhanced sensing.
- Utilized a light source for self-powered operation and photoelectrochemical detection.
Main Results:
- The biosensor demonstrated a linear detection range from 10 nM to 100 μM.
- Achieved a low detection limit of 4.1 nM and a rapid response time of 0.7 s.
- Exhibited excellent resistance to interference from common tear components due to enzyme selectivity.
Conclusions:
- The developed non-invasive tear glucose biosensor provides an effective method for glucose detection.
- The self-powered, integrated design is suitable for analyzing small sample volumes.
- Offers valuable insights for designing future non-invasive and self-powered biosensors.
