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miRNAs Role in Wilms tumor pathogenesis: Signaling pathways interplay

Jaber Alfaifi1

  • 1Department of Child Health, College of Medicine, University of Bisha, Bisha 61922, Saudi Arabia.

Pathology, Research and Practice
|March 9, 2024
PubMed

Insights

MicroRNAs (miRNAs) play a key role in childhood Wilms' tumors (WTs) by regulating gene expression. This review summarizes how their dysregulation contributes to WT development and progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Wilms' tumors (WTs) are the most common pediatric kidney cancer.
  • Anaplastic WTs are associated with a poor prognosis.
  • MicroRNAs (miRNAs) are critical regulators of gene expression involved in development.

Purpose of the Study:

  • To review the current understanding of microRNA dysregulation in Wilms' tumor development.
  • To highlight the role of oncogenic and tumor-suppressing miRNAs in WT progression.
  • To consolidate knowledge on miRNA involvement in renal pathologies.

Main Methods:

  • Literature review of studies on microRNAs and Wilms' tumors.
  • Analysis of research connecting miRNA dysregulation to renal diseases.
  • Synthesis of findings on specific miRNAs in WT pathogenesis.

Main Results:

  • MicroRNA dysregulation is implicated in the development of various renal diseases, including fibrosis, cancer, and cystic kidney disease.
  • Specific oncogenic and tumor-suppressing miRNAs have been identified as dysregulated in Wilms' tumors.
  • Altered miRNA expression patterns are linked to the progression of WT.

Conclusions:

  • MicroRNAs are significant players in the pathogenesis of Wilms' tumors.
  • Understanding miRNA roles offers potential therapeutic targets for WT.
  • Further research into miRNA mechanisms is crucial for improving pediatric kidney cancer treatment.
Keywords:
MiRNAsPathogenesisWilms’ tumornephroblastoma

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