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Defining domains: developing consensus-based definitions for foundational domains in OMERACT core outcome sets.

Lara J Maxwell1, Caitlin Jones2, Clifton O Bingham3

  • 1Faculty of Medicine, University of Ottawa and Ottawa Hospital Research Institute, Centre for Practice Changing Research, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada.

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|March 9, 2024
PubMed
Summary
This summary is machine-generated.

Researchers defined five core domains for Outcome Measures in Rheumatology (OMERACT) studies, enhancing consistency in rheumatology research. Patient global assessment requires further investigation for standardized definitions.

Keywords:
Core domain setDomainsOMERACTOutcome methodologyRheumatology

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Area of Science:

  • Rheumatology
  • Outcomes Research
  • Measurement Science

Background:

  • Outcome Measures in Rheumatology (OMERACT) utilizes core domain sets for clinical trials.
  • Standardized definitions are crucial for consistent data collection and interpretation in rheumatology outcomes research.

Purpose of the Study:

  • To develop detailed, consensus-based definitions for foundational domains within OMERACT core domain sets.
  • To enhance the clarity and consistency of outcome measures used in rheumatology research.

Main Methods:

  • Systematic identification of candidate domain definitions from existing literature and organizational guidelines.
  • Two-round Delphi survey administered to OMERACT working groups, patient research partners, and the Technical Advisory Group.
  • Consensus-building discussions and contextualization of definitions using lived experience at the OMERACT 2023 Methodology Workshop.

Main Results:

  • Consensus was reached on detailed definitions for five foundational domains: pain intensity, pain interference, physical function, fatigue, and health-related quality of life.
  • A preferred definition for patient global assessment could not be established, indicating a need for further research.
  • Lived experience examples were incorporated to contextualize the finalized domain definitions.

Conclusions:

  • A consensus-based approach successfully yielded detailed definitions for five key OMERACT domains.
  • These standardized definitions aim to streamline the instrument selection process and reduce resource requirements for future OMERACT core outcome set development.
  • Further research is necessary to establish a consensus definition for patient global assessment.