Related Experiment Video
Updated: Jul 1, 2025
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Prolonged renal function impairment in infants born during the peri-viable period: A retrospective longitudinal
Kyosuke Ibi1, Naoto Takahashi1
1Department of Pediatrics, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-Ku, Tokyo 113-8655, Japan.
Insights
Infants born prematurely show improving but persistent renal insufficiency even at term equivalent age. Further follow-up beyond the neonatal period is recommended for these high-risk infants.
Area of Science:
- Neonatal research
- Pediatric nephrology
- Perinatal medicine
Background:
- Survival rates for infants born during the peri-viable period are increasing.
- Understanding the long-term health outcomes of these infants is crucial.
Conclusions:
- Peri-viable infants exhibit persistent renal insufficiency around term equivalent age.
- Long-term follow-up data beyond the neonatal period is essential for these infants.
Background:
The number of infants born during the peri-viable period who survive has been increasing.
Aim:
To clarify renal function in infants from the time of birth during the peri-viable period until their due date.
Study Design:
This retrospective cohort study was conducted at a single center.
Subjects:
We reviewed the data of infants born at ≤28 weeks of gestation between 2018 and 2022 at our hospital. The infants were divided into the following groups: born at 22-24 weeks vs. 25-28 weeks (appropriate-for-gestational age [AGA] infants), and AGA infants vs. small-for-gestational age (SGA) infants (born at 22-28 weeks).
Outcome Measures:
We compared the perinatal data and renal function of the infants from birth until their due date.
Results:
Eighty-one infants were included. Their serum creatinine, fractional excretion of sodium, and urine glucose levels were high or positive soon after birth but gradually improved. The urine albumin level was significantly higher among AGA infants born at 22-24 weeks, even at term equivalent age, than among those born at 25-28 weeks.
Conclusions:
Persistent renal insufficiency was observed even around the term equivalent age in peri-viable infants. Follow-up data collected after the neonatal period should be investigated in these infants.
