Transitioning biomedical research toward human-centric methodologies: systems-based strategies

Area of Science:

• Biomedical research
• Public health
• Methodological innovation

Background:

• Traditional animal models face limitations in fully representing human biology and public health needs.
• Despite advancements in human-centric methodologies, such as microphysiological systems and in silico methods, the reliance on animal research continues.
• A gap exists in effectively translating innovative research methods into policy and practice.

Purpose of the Study:

• To propose a systemic thinking approach to reframe the debate around research methodology selection.
• To provide policymakers with a novel framework for developing more effective strategies in basic and biomedical research.
• To encourage the adoption of innovative, human-centric methods by addressing the systemic factors influencing their implementation.

Main Methods:

• Analysis of factors influencing research method selection in basic and biomedical research.
• Development of a simplified model to illustrate the systemic nature of decision-making in methodology adoption.
• Leveraging systemic thinking principles endorsed by organizations like the OECD and EU.

Main Results:

• Identification of complex factors that shape the choice between animal-based and human-centric research methods.
• A conceptual model demonstrating the interconnectedness of influences on methodology adoption.
• Highlighting the need for a systemic perspective to overcome barriers to innovation.

Conclusions:

• A systemic thinking approach offers a powerful framework for policymakers to drive transformative change in research methodologies.
• Effective policy requires understanding the complex system of influences on method selection, not just isolated factors.
• Collaboration among stakeholders and the generation of robust data are crucial for successful implementation of innovative, human-centric research approaches.