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Transitioning biomedical research toward human-centric methodologies: systems-based strategies.

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Human-centric research methods show promise but animal models persist. A systemic thinking approach can help policymakers adopt innovative strategies for better human biology research and public health outcomes.

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animal modelsbiomedical researchhuman-centric methodologiespolicypublic health challengessystemic thinking

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Area of Science:

  • Biomedical research
  • Public health
  • Methodological innovation

Background:

  • Traditional animal models face limitations in fully representing human biology and public health needs.
  • Despite advancements in human-centric methodologies, such as microphysiological systems and in silico methods, the reliance on animal research continues.
  • A gap exists in effectively translating innovative research methods into policy and practice.

Purpose of the Study:

  • To propose a systemic thinking approach to reframe the debate around research methodology selection.
  • To provide policymakers with a novel framework for developing more effective strategies in basic and biomedical research.
  • To encourage the adoption of innovative, human-centric methods by addressing the systemic factors influencing their implementation.

Main Methods:

  • Analysis of factors influencing research method selection in basic and biomedical research.
  • Development of a simplified model to illustrate the systemic nature of decision-making in methodology adoption.
  • Leveraging systemic thinking principles endorsed by organizations like the OECD and EU.

Main Results:

  • Identification of complex factors that shape the choice between animal-based and human-centric research methods.
  • A conceptual model demonstrating the interconnectedness of influences on methodology adoption.
  • Highlighting the need for a systemic perspective to overcome barriers to innovation.

Conclusions:

  • A systemic thinking approach offers a powerful framework for policymakers to drive transformative change in research methodologies.
  • Effective policy requires understanding the complex system of influences on method selection, not just isolated factors.
  • Collaboration among stakeholders and the generation of robust data are crucial for successful implementation of innovative, human-centric research approaches.