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Updated: Jul 11, 2026
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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
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SUMF1 overexpression promotes tumorous cell growth and migration and is correlated with the immune status of patients
Ping Zhang1, Zhao Liu2, Yu-Yu Wang1
1Department of Neurosurgery, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.
Aging
|March 9, 2024
Summary
Sulfatase modifying factor 1 (SUMF1) is overexpressed in glioma, correlating with poor prognosis and altered immune microenvironment. Inhibiting SUMF1 may impede glioma cell growth and invasion, offering potential therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Glioma is a common malignant brain tumor.
- Limited research exists on the role of sulfatase modifying factor 1 (SUMF1) in glioma.
Purpose of the Study:
- To investigate the association between SUMF1 and glioma diagnosis, prognosis, and immune microenvironment.
- To develop predictive models for glioma patient outcomes based on SUMF1 levels.
Main Methods:
- Examined SUMF1 expression in glioma tissues.
- Utilized Cox and Lasso regression for nomogram and risk model construction.
- Performed functional experiments including gene ontology, cell viability, migration, invasion, and western blotting.
Main Results:
- SUMF1 expression is elevated in glioma and linked to adverse diagnosis, survival, and histological factors.
- SUMF1 overexpression is an independent predictor of poor prognosis and is associated with immune cell infiltration and immune scores.
- SUMF1 inhibition reduced glioma cell proliferation, migration, and invasion via epithelial-mesenchymal transition.
Conclusions:
- SUMF1 overexpression correlates with poor prognosis, immune status, and cancer detection in glioma.
- SUMF1-based nomograms and risk models can predict glioma patient outcomes.
- Targeting SUMF1 presents a potential therapeutic strategy for glioma.
