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Updated: Jul 1, 2025
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Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
Published on: July 6, 2013
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CMV-encoded GPCRs in infection, disease, and pathogenesis
William E Miller1, Christine M O'Connor2
1Department of Molecular and Cellular Bioscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Advances in Virus Research
|March 9, 2024
Summary
Cytomegalovirus (CMV) encodes viral G protein coupled receptors (vGPCRs) that significantly impact viral infection and disease. This review explores their roles in lytic and latent infections, enhancing our understanding of viral pathogenesis.
Area of Science:
- Virology
- Molecular Biology
- Cellular Biology
Background:
- G protein coupled receptors (GPCRs) are crucial membrane proteins regulating cellular functions.
- Cytomegaloviruses (CMVs), a type of betaherpesvirus, encode their own viral GPCRs (vGPCRs).
- Human CMV (HCMV) possesses four distinct vGPCRs: UL33, UL78, US27, and US28.
Purpose of the Study:
- To review the functional roles of CMV-encoded vGPCRs.
- To elucidate the impact of vGPCRs on viral pathogenesis during infection.
- To discuss the involvement of vGPCRs in both lytic and latent viral infection stages.
Main Methods:
- Literature review of studies on CMV vGPCRs.
- Analysis of research investigating vGPCRs in viral infection and disease.
- Synthesis of findings on the function and impact of vGPCRs.
Main Results:
- CMV vGPCRs are implicated in modulating host cell processes.
- These viral receptors contribute to the pathogenesis of CMV infections.
- vGPCRs play roles throughout the viral life cycle, including latency.
Conclusions:
- CMV vGPCRs are key viral factors influencing infection dynamics and disease.
- Further research into vGPCRs can reveal novel therapeutic targets.
- Understanding vGPCR function is essential for combating CMV-related illnesses.
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