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Updated: Jul 1, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
NLRC5/MHC class I transactivator: A key target for immune escape by SARS-CoV-2
Baohui Zhu1, Ryota Ouda1, Yusuke Kasuga1
1Department of Immunology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Abstract:
Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS-CoV-2 infection studies and analysis of COVID-19 patient samples, we found that SARS-CoV-2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I genes. In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID-19.
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