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Updated: Jul 1, 2025

Motor Dual-Tasks for Gait Analysis and Evaluation in Post-Stroke Patients
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Cognitive function influences cognitive-motor interference during dual task walking in multiple sclerosis.

Wan-Yu Hsu1, Valerie J Block2, Jaeleene Wijangco1

  • 1Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, 1651 4th street, San Francisco, CA, USA.

Multiple Sclerosis and Related Disorders
|March 10, 2024
PubMed
Summary
This summary is machine-generated.

Cognitive impairments in multiple sclerosis (MS) patients are linked to greater cognitive-motor interference (CMI) during dual-task walking. Lower cognitive function in people with MS correlated with increased CMI, impacting gait performance.

Keywords:
CognitionCognitive-motor interferenceDual task costDual-task walkingMultiple sclerosis

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Area of Science:

  • Neuroscience
  • Rehabilitation Science
  • Clinical Neurology

Background:

  • Multiple Sclerosis (MS) frequently causes both physical and cognitive deficits.
  • Dual-task walking (performing a cognitive task while walking) can reveal cognitive-motor interference (CMI) and alter gait.
  • The relationship between cognitive impairment severity and CMI in MS is not well understood.

Purpose of the Study:

  • To investigate the association between cognitive functioning levels and the degree of CMI in people with MS (PwMS).
  • To determine how cognitive status influences gait adjustments during dual-task walking.

Main Methods:

  • Ninety-five PwMS completed single- and dual-task walking trials at their preferred pace.
  • Dual Task Costs (DTC) were calculated from gait parameters to quantify CMI.
  • Cognitive function was assessed using the Match test; participants were classified as lower (LCF) or higher (HCF) cognitive functioning based on a z-score.

Main Results:

  • The LCF group exhibited significantly higher DTC for stride velocity compared to the HCF group.
  • A negative correlation was observed between stride velocity DTC and cognitive performance on the Match test.

Conclusions:

  • The study supports the hypothesis that CMI during walking is associated with cognitive functioning levels in PwMS.
  • Cognitive impairment directly impacts the ability of people with MS to manage dual-task walking.