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Optimal blood pressure for stroke prevention in healthy adults below 65 years: A nationwide 10-year observational

So Im Ryu1, Sang Hyo Lee2, Hyoung Soo Byoun3

  • 1Department of Nursing, Changwon National University, Changwon-si, Republic of Korea.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|March 10, 2024
PubMed

Insights

Maintaining blood pressure (BP) below Stage 1 hypertension is crucial for preventing stroke in adults under 65. This study confirms the importance of the 2017 hypertension guidelines for stroke prevention.

Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Few studies have examined the preventative value of intensive blood pressure (BP) management for stroke following the 2017 American College of Cardiology/American Heart Association (ACC/AHA) hypertension (HTN) guidelines.
  • The 2017 ACC/AHA guidelines redefined hypertension criteria, necessitating updated research on optimal BP targets for stroke prevention.

Purpose of the Study:

  • To identify the optimal blood pressure (BP) threshold for preventing stroke in healthy adults under 65 years of age.
  • To evaluate the association between different BP categories and the risk of hemorrhagic stroke (HS) and ischemic stroke (IS) in a large cohort.

Main Methods:

  • A 10-year observational study utilizing the National Health Insurance Service Database.
  • Stroke risk was analyzed across BP categories: low-normal BP, high-normal BP, elevated BP, stage 1 HTN, and stage 2 HTN.
  • Included 949,551 participants who underwent health checkups in 2008.

Main Results:

  • The risk of hemorrhagic stroke (HS) significantly increased starting from stage 2 HTN in men and stage 1 HTN in women.
  • The risk of ischemic stroke (IS) increased in both men and women with stage 1 HTN.
  • Overall stroke risk was elevated in both men and women diagnosed with stage 1 HTN.

Conclusions:

  • Maintaining blood pressure below Stage 1 hypertension is essential for preventing stroke in healthy adults under 65.
  • These findings reinforce the clinical significance of the 2017 ACC/AHA hypertension guidelines for proactive stroke prevention strategies.
Abstract

Keywords:
Blood pressureHemorrhagic strokeHypertensionIschemic strokePrimary preventionRisk factorsStroke

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