Central and peripheral corneal sagittal height in keratoconus and healthy eyes

To determine central and peripheral corneal sagittal height (z) values in keratoconus and healthy eyes with the Oculus Pentacam point-by-point data extraction software.

Forty eyes from patients with central or paracentral (4 mm) keratoconus (32.0 ± 12.5 years) and 40 eyes from healthy subjects (29.1 ± 7.9 years) were included. The Oculus Pentacam software was employed to determine z values referenced to a plane tangent to the corneal apex for five circles concentric with the centre of the pupil with diameters 4, 6, 8, 9 and 10.5 mm. The variability in z values within each circle and in terms of corneal meridians and quadrants was explored in keratoconus and healthy eyes.

Keratoconus apex was mainly located at the inferior-temporal quadrant, at a distance from 0.083 mm to 3.59 mm with reference to the centre of the pupil. Mean z was larger in keratoconus than in healthy eyes in all explored corneal diameters (all p < 0.001). Variation in z values was larger in keratoconus than healthy eyes only at the central areas of the cornea (4 mm, p = 0.02; 6 mm, p = 0.011), but not in the periphery (8, 9 and 10.5 mm). In keratoconus, the frequency of minimum z values in the IT quadrant was greater than in healthy eyes.

Although peripheral z values were larger in keratoconus, rotational variations were comparable between keratoconus and healthy eyes, suggesting that large diameter spherical rigid corneal contact lenses may be an alternative to scleral lenses in central and paracentral keratoconus.