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Age-associated reduction of sinus macrophages in human mesenteric lymph nodes

Kosuke Kanemitsu1,2, Rin Yamada1,3, Cheng Pan1

  • 1Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Journal of Clinical and Experimental Hematopathology : JCEH
|March 10, 2024
PubMed

Insights

Sinus macrophages (SMs), vital for immune responses, significantly decrease in lymph nodes of elderly patients, especially those over 80. This reduction in SMs may explain age-related immune dysfunction.

Area of Science:

  • Immunology
  • Gerontology
  • Oncology

Background:

  • Lymph nodes (LNs) contain numerous macrophages and dendritic cells.
  • Sinus macrophages (SMs) in LNs exhibit antigen-presenting capabilities and are linked to anti-cancer immunity.

Purpose of the Study:

  • To investigate the distribution of SMs in mesenteric LNs from colorectal cancer patients.
  • To assess the impact of age on SM populations in LNs.

Main Methods:

  • Analysis of mesenteric LNs from colorectal cancer patients undergoing surgery.
  • Observation of CD169-positive cell presence in LNs.
  • In silico analysis of single-cell RNA sequencing data from LNs.

Main Results:

  • A significant reduction in SMs was observed in elderly patients (over 80 years old).
  • CD169-positive cells were absent in LNs with reduced SMs.
  • In silico analysis indicated CD169-positive macrophages share functions with dendritic cells, including antigen presentation and lymphocyte proliferation.

Conclusions:

  • Sinus macrophages (SMs) diminish in the lymph nodes of elderly patients.
  • The reduction of SMs may contribute to age-related immune dysfunction.
  • SMs play a crucial role in immune activation within lymph nodes.
Keywords:
colorectal cancerlymph nodesinus macrophage

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