Related Experiment Video
Updated: Jul 1, 2025
08:51
Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
1.2K
[Biomarkers of Inflammation in Predicting the Outcomes of Heart Failure of Ischemic Etiology: the Results of Factor
A A Garganeeva1, E A Kuzheleva1, O V Tukish1
1Research Institute of Cardiology, Tomsk National Research Medical Center.
Kardiologiia
|March 11, 2024
Summary
A combination of inflammatory markers, including neutrophil gelatinase-associated lipocalin (NGAL), growth/differentiation factor 15 (GDF-15), neutrophil-to-lymphocyte ratio (NLR), and fibrinogen, can predict cardiovascular death in chronic heart failure patients with coronary atherosclerosis.
Area of Science:
- Cardiology
- Inflammation Research
- Biomarker Discovery
Background:
- Chronic heart failure (CHF) and coronary atherosclerosis are significant contributors to cardiovascular morbidity and mortality.
- Subclinical inflammation plays a crucial role in the progression of cardiovascular disease.
Purpose of the Study:
- To investigate the prognostic value of specific inflammatory biomarkers in patients with CHF and multivessel coronary atherosclerosis.
- To identify a distinct set of biomarkers reflecting subclinical inflammation associated with adverse cardiovascular outcomes.
Main Methods:
- A prospective observational study involving 80 patients with CHF scheduled for coronary artery bypass grafting (CABG).
- Assessed inflammatory biomarkers: NGAL, GDF-15, FGF-23, TGF-β1, hs-CRP, and NLR, alongside routine tests and coagulation parameters.
- Follow-up of at least 12 months (median 16 months) to record cardiovascular events.
Main Results:
- Factor analysis identified a combined factor including NGAL, GDF-15, NLR, and fibrinogen.
- This inflammatory marker set was significantly associated with mortality in CHF patients with coronary atherosclerosis.
- The association remained significant after adjusting for key clinical factors like age, renal function, and comorbidities.
Conclusions:
- A composite inflammatory marker factor (NGAL, GDF-15, NLR, fibrinogen) effectively reflects subclinical inflammation in CHF patients with stenotic coronary atherosclerosis.
- This factor serves as a valuable predictor of long-term cardiovascular death risk following surgical myocardial revascularization.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
91
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
91
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
153
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
153
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
429
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
429