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Extensively Hydrolyzed Formula and Infant Colic Symptoms: Secondary Analysis of a Prospective Cohort Study
Jerry Mack Brown1, Jessica Victoria Baran1, Luke Lamos1
1Office of Medical Education, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
Insights
Healthcare providers prioritize safety, tolerability, and efficacy when selecting alternative extensively hydrolyzed formulas for infants with cow
Area of Science:
- Pediatric Allergy and Immunology
- Infant Nutrition
- Clinical Decision-Making
Background:
- Cow's milk protein allergy (CMPA) impacts 2-3% of infants, typically managed with specialized hypoallergenic formulas.
- Recent infant formula recalls and subsequent shortages have complicated CMPA management.
- Limited research exists on pediatric healthcare providers' (HCPs) decision-making processes during formula shortages.
Purpose of the Study:
- To investigate the factors influencing HCPs' choices when transitioning infants to alternative extensively hydrolyzed formulas during shortages.
- To understand the specific considerations pediatric physicians employ when managing CMPA amidst supply chain disruptions.
Main Methods:
- A de-identified survey was distributed to US-based HCPs.
- 104 eligible participants included general pediatricians, pediatric allergists/immunologists, and pediatric gastroenterologists.
- The survey assessed key decision-making drivers for switching extensively hydrolyzed formulas.
Main Results:
- Safety, tolerability, and efficacy were the primary factors cited by HCPs for formula selection.
- A specific formula (Formula 1) was consistently reported as well-tolerated, safe, and effective by participants.
- HCPs expressed strong confidence in Formula 1's safety and efficacy profile.
Conclusions:
- Findings provide critical insights into HCPs' strategies for managing CMPA during formula shortages.
- The study highlights the importance of safety, tolerability, and efficacy in guiding formula selection.
- Recommendations can enhance infant care and support HCPs in navigating formula supply challenges.
Abstract:
Cow's milk protein allergy (CMPA) affects 2% to 3% of infants and is managed with hypoallergenic formulas. The 2022 recalls of infant formulas due to factors including contamination led to specialty formula shortages, highlighting CMPA management challenges. Understanding health care providers' (HCPs) decision-making in transitioning to alternative formulas during shortages is crucial. Limited attention has been given to how pediatric physicians make these choices. This study utilized US HCPs' de-identified survey data to assess driving factors when switching extensively hydrolyzed formulas during shortages. A total of 104 eligible HCPs participated, including general pediatrics, pediatric allergy/immunology, and pediatric gastroenterology specialists. Safety, tolerability, and efficacy were identified as top factors for switching formulas. Formula 1 was considered well-tolerated, patient-accepted, and safe by all HCPs. Most expressed strong belief in Formula 1's safety and effectiveness. Findings inform CMPA management during shortages, offering guidance to HCPs for suitable formula selection and enhanced infant care.
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