Related Experiment Video
Updated: Jul 1, 2025
06:33
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
7.7K
Gastroduodenal Involvement in AL Amyloidosis: Case Report and Literature Review
Rajarajeshwari Ramachandran1, Tyler Grantham2, Giovannie Isaac-Coss1
1Brooklyn Hospital Center, NY, USA.
Journal of Investigative Medicine High Impact Case Reports
|March 11, 2024
Summary
Gastrointestinal amyloidosis, a rare condition often linked to systemic AL amyloidosis, can cause diverse GI symptoms. Diagnosis involves biopsy, and management focuses on treating the underlying cause and symptoms.
Area of Science:
- Gastroenterology
- Hematology
- Pathology
Background:
- Gastrointestinal amyloidosis is a rare manifestation of systemic AL amyloidosis.
- Amyloid deposition in the GI tract leads to varied symptoms, including pain, weight loss, bleeding, malabsorption, dysmotility, and obstruction.
Approach:
- This case report details a patient with IgG lambda AL amyloidosis presenting with epigastric pain and weight loss.
- Gastroduodenal amyloidosis was diagnosed via endoscopic biopsy, Congo red staining, and polarized light microscopy.
Key Points:
- Definitive diagnosis of GI amyloidosis requires specific histopathological examination.
- Management strategies are not standardized but generally involve treating the underlying systemic cause and managing GI symptoms.
- The patient received cyclophosphamide, bortezomib, and dexamethasone (CyBorD) and initiated hemodialysis for renal disease progression.
Conclusions:
- Gastrointestinal amyloidosis presents a diagnostic and management challenge.
- Multidisciplinary care is essential for patients with systemic amyloidosis and GI involvement.
Related Concept Videos
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
117
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
117
03:03Amyloid Fibrils
9.5K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.5K
01:17Gastritis-II: Pathophysiology
326
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
326
01:50What is Monogastric Digestion?
71.2K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.2K
01:30Peptic Ulcer Disease I: Introduction
168
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
168
01:27Gastritis-I: Introduction and Types
404
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
404