Related Experiment Video
Updated: May 6, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 18, 2014
Adult congenital heart diseases: systematic review/meta-analysis
Ahmdelmukashfi M Elmustfa A Azem Mahmod1, Shima Hassan Mohammed Koko2
1Faculty of Medicine and Health Sciences, Red Sea University, Port Sudan.
Insights
Adults with congenital heart disease (CHD) report a lower quality of life (QOL) across all aspects. Factors like age, anxiety, depression, and female gender contribute to diminished QOL in CHD patients.
Area of Science:
- Cardiology
- Public Health
- Quality of Life Research
Background:
- Congenital heart disease (CHD) represents significant structural heart abnormalities impacting patient function.
- Assessing the quality of life (QOL) for CHD patients is crucial for researchers and clinicians.
- A systematic review is needed to consolidate existing knowledge on CHD patient QOL.
Purpose of the Study:
- To systematically review and assess the quality of life (QOL) in adult patients diagnosed with congenital heart disease (CHD).
Main Methods:
- Searched PubMed and Google Scholar for studies published between 2020-2022.
- Utilized keywords: "QOL, Adults, CHD, Outcomes, Impact, Effects, Life of CHD Patients."
- Included original, full-text English articles focusing on adult CHD patients' QOL.
Main Results:
- Seven eligible studies were identified from 5455 initial articles.
- The review encompassed 8445 adult CHD patients and 104 healthy controls.
- Investigated QOL dimensions included physical/psychological health, mental well-being, anxiety, and depression.
Conclusions:
- Adults with congenital heart disease consistently report a reduced quality of life.
- Risk factors for poor QOL in this population include older age, anxiety, depression, and being female.
Background:
Congenital heart disease (CHD) is a gross structural abnormality of the heart that has functional significance. The impact of CHD on the patients' quality of life (QOL) is a topic of considerable interest and importance to both researchers and clinician. However, there is a lack of systematic reviews investigating and identifying the QOL of congenital heart disease patients.
Aim:
To assess the QOL of adult patients with congenital heart disease by reviewing the previous studies conducted on this subject.
Methods:
The PubMed and Google Scholar databases were explored for studies published between 2020 and 2022. The keywords used for the searching process included "QOL, Adults, CHD, Outcomes, Impact, Effects, Life of CHD Patients." The inclusion criteria were original English articles and full-text articles conducted on adult patients with congenital heart disease and reported quality of life.
Results:
A total of 5455 articles were obtained, but only seven articles were eligible for the inclusion criteria. The included studies involved a total of 8549 participants; 104 were healthy, and 8445 were adult patients with congenital heart disease. The investigated items of the studies included quality of life, health-related QOL, including physical and psychological dimensions, sense of coherence, mental health, physical functioning, physiological wellbeing, psychological resilience, anxiety, depression, illness perception, and health status.
Conclusion:
Patients with congenital heart disease experience low QOL across all dimensions. The risk factors for poor QOL included age, depression, anxiety, and female gender.
Related Concept Videos
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Rheumatic Heart Disease I: Introduction
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Rheumatic Heart Disease III: Medical Management
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy V: Interprofessional Care

