A Comprehensive Review of Various Therapeutic Strategies for the Management of Skin Cancer
Sudharshan Reddy Dachani1, Mohammed Kaleem2, Md Ali Mujtaba3
1Department of Pharmacy Practice, College of Pharmacy, Shaqra University, Al-Dawadmi Campus, Al-Dawadmi 11961, Saudi Arabia.
Abstract:
Skin cancer (SC) poses a global threat to the healthcare system and is expected to increase significantly over the next two decades if not diagnosed at an early stage. Early diagnosis is crucial for successful treatment, as the disease becomes more challenging to cure as it progresses. However, identifying new drugs, achieving clinical success, and overcoming drug resistance remain significant challenges. To overcome these obstacles and provide effective treatment, it is crucial to understand the causes of skin cancer, how cells grow and divide, factors that affect cell growth, and how drug resistance occurs. In this review, we have explained various therapeutic approaches for SC treatment via ligands, targeted photosensitizers, natural and synthetic drugs for the treatment of SC, an epigenetic approach for management of melanoma, photodynamic therapy, and targeted therapy for BRAF-mutated melanoma. This article also provides a detailed summary of the various natural drugs that are effective in managing melanoma and reducing the occurrence of skin cancer at early stages and focuses on the current status and future prospects of various therapies available for the management of skin cancer.
Insights
Early skin cancer (SC) diagnosis is vital for effective treatment and overcoming drug resistance. This review explores diverse therapeutic strategies, including natural drugs and targeted therapies, for managing SC and melanoma.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Skin cancer (SC) presents a growing global health challenge, with increasing incidence projected.
- Early diagnosis is critical for successful SC treatment outcomes.
- Drug resistance and treatment efficacy remain significant hurdles in SC management.
Purpose of the Study:
- To review current and emerging therapeutic approaches for skin cancer (SC) treatment.
- To elucidate the importance of understanding SC pathogenesis, cell growth, and drug resistance mechanisms.
- To summarize natural compounds and targeted therapies for SC and melanoma management.
Main Methods:
- Comprehensive literature review of therapeutic strategies for skin cancer.
- Analysis of various treatment modalities including ligands, photosensitizers, and epigenetic approaches.
- Focus on natural and synthetic drugs, photodynamic therapy, and targeted therapy for BRAF-mutated melanoma.
Main Results:
- Various therapeutic approaches for SC are detailed, including ligands, targeted photosensitizers, and natural/synthetic drugs.
- Epigenetic strategies and photodynamic therapy show promise for melanoma management.
- Natural drugs are highlighted for their efficacy in early-stage SC and melanoma management.
Conclusions:
- Understanding SC biology is key to developing effective treatments and overcoming resistance.
- A range of therapeutic options, from natural compounds to targeted therapies, are available for SC.
- Future research should focus on optimizing existing therapies and exploring novel treatment avenues for skin cancer.
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