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Updated: Jul 1, 2025

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
Published on: September 12, 2019
The Clinical and Pathological Characteristics of POLE-Mutated Endometrial Cancer: A Comprehensive Review
Xiaohong Yao1, Min Feng1,2, Wei Wang1,2
1Department of Pathology, West China Second University Hospital, Sichuan University, Sichuan, Chengdu, People's Republic of China.
Abstract:
Endometrial cancer shows high histological and molecular heterogeneity. The POLE mutation is a significant molecular alteration in endometrial cancer, leading to the identification of a specific subtype known as POLE-mutated endometrial cancer. This subtype exhibits a high tumor mutation burden, abundant lymphocyte infiltration, and a favorable prognosis, making it a promising candidate for immune checkpoint inhibitor therapy. This paper presents a comprehensive review of the clinical and pathological characteristics, outcomes, treatment advancements, pathogenic POLE gene detection, and alternative testing methods for POLE-mutated endometrial cancer.
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