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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...

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Updated: Jul 1, 2025

The Determination of Protease Specificity in Mouse Tissue Extracts by MALDI-TOF Mass Spectrometry: Manipulating PH to Cause Specificity Changes

The Determination of Protease Specificity in Mouse Tissue Extracts by MALDI-TOF Mass Spectrometry: Manipulating PH to Cause Specificity Changes

Published on: May 25, 2018

Plant cathepsin B, a versatile protease.

Marianna Coppola¹, Lukas Mach², Patrick Gallois¹

¹Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Frontiers in Plant Science

|March 11, 2024

Summary

This summary is machine-generated.

Plant cathepsin B, a versatile cysteine protease, impacts plant development, stress responses, and programmed cell death. Further research into its cell signaling roles is crucial for plant biotechnology applications.

Keywords:

CTS-B abiotic stress apoplast biotic stress germination programmed cell death senescence vacuole

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Area of Science:

Plant molecular biology
Enzymology
Biochemistry

Background:

Plant proteases are vital enzymes involved in protein turnover, signaling, and genetically controlled processes.
Cathepsin B, a cysteine protease with exopeptidase and endopeptidase activity, plays dual roles in plants.
While extensively studied in animals, plant cathepsin B functions remain less understood.

Purpose of the Study:

To review the structural features and activities of plant cathepsin B.
To compare plant and animal cathepsin B forms.
To detail the involvement of cathepsin B in crucial plant life processes and its potential in biotechnology.

Main Methods:

Literature review focusing on plant cathepsin B research.
Comparative analysis of plant and animal cathepsin B structures and functions.
Synthesis of current knowledge on cathepsin B's roles in plant development, stress, and cell death.

Main Results:

Cathepsin B participates in plant development, germination, senescence, and defense mechanisms.
It is implicated in responses to abiotic stress and programmed cell death.
Differences in maturation and subcellular localization exist between plant and animal cathepsin B.

Conclusions:

Plant cathepsin B is a key enzyme with diverse roles in plant physiology and stress responses.
Understanding its cell signaling pathways is essential for advancing plant biotechnology.
Further investigation is needed to fully elucidate the mechanisms and applications of plant cathepsin B.