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Published on: August 2, 2017
Predictive value of coagulation function, alpha-fetoprotein and placental growth factor in patients with perilous
Yuan Qiao1, Jin Xiao1, Tongqiang He1
1Obstetrics and Gynecology Intensive Care Unit, Northwest Women's and Children's Hospital No. 1616 Yanxiang Road, Xi'an 710061, Shaanxi, China.
Objective:
To analyze the predictive value of coagulation function, alpha-fetoprotein (AFP) and placental growth factor (PIGF) for postpartum hemorrhage in patients with perilous placenta previa (PPP).
Methods:
The clinical data of 104 PPP patients were retrospectively analyzed. The patients were divided into a hemorrhage group (n=68) and a non-hemorrhage group (n=36). A total of 55 healthy pregnant women were recruited as controls. The coagulation function, AFP and PIGF were compared between the three groups. Multivariate logistic regression was performed to determine independent risk factors for hemorrhage.
Results:
PT, TT, APTT, FIB and AFP were significantly higher while PIGF was lower in the PPP group than the control group (all P<0.05). Placental adhesion (OR 3.924, 95% CI 1.389-11.083, P=0.01), anterior placenta (OR 4.583, 95% CI 1.589-13.22, P=0.005), AFP (OR 0.208, 95% CI 0.068-0.635, P=0.006) and PIGF (OR 3.963, 95% CI 1.385-11.34, P=0.01) were independent risk factors for hemorrhage.
Conclusion:
Coagulation function, AFP and PIGF could predict postpartum hemorrhage in PPP patients.
