Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

7.2K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.2K
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

2.6K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
2.6K
The Extracellular Matrix01:42

The Extracellular Matrix

82.5K
Overview
82.5K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

2.5K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
2.5K
Extracellular Matrix01:26

Extracellular Matrix

2.9K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
2.9K
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

6.7K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pink1-mediated mitophagy in the endothelium releases proteins encoded by mitochondrial DNA and activates neutrophil responses during inflammation.

eLife·2026
Same author

Telomerase-mediated immortalization preserves the anti-inflammatory activity of dental pulp stem cell extracellular vesicles.

Frontiers in immunology·2026
Same author

3D-Printed Porous Titanium versus Polyetheretherketone Cages in Lumbar Interbody Fusion: A Prospective, Multicenter, Randomized Controlled Trial with Bone Mineral Density Stratification.

The spine journal : official journal of the North American Spine Society·2026
Same author

Optimizing Postoperative Sagittal Alignment: The Effect of Pedicle Screw Fixation in 540° Combined Surgery for Degenerative Cervical Disease.

Global spine journal·2026
Same author

Machine learning-driven single-cell phenotyping in size-controlled microenvironments <i>via</i> parallel deterministic droplet microfluidics.

Lab on a chip·2026
Same author

Community-engaged analysis of soil lead contamination near a historical metallurgy facility in Los Angeles, California.

Environmental science and pollution research international·2026

Related Experiment Video

Updated: Jul 1, 2025

2D and 3D Matrices to Study Linear Invadosome Formation and Activity
12:25

2D and 3D Matrices to Study Linear Invadosome Formation and Activity

Published on: June 2, 2017

10.0K

Extracellular vesicle-matrix interactions.

Koushik Debnath1,2, Kevin Las Heras1,2,3,4, Ambar Rivera1,2,5

  • 1Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

Nature Reviews. Materials
|March 11, 2024
PubMed
Summary
This summary is machine-generated.

Extracellular vesicles (EVs) interact with the extracellular matrix, influencing tissue function. Understanding these interactions enables engineered biomaterials for precise therapeutic EV delivery.

Keywords:
biomaterialsextracellular matrixextracellular vesiclenanoscale biophysicsnanotechnology

More Related Videos

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

11.0K
Purification and Analysis of Caenorhabditis elegans Extracellular Vesicles
09:30

Purification and Analysis of Caenorhabditis elegans Extracellular Vesicles

Published on: March 31, 2020

7.6K

Related Experiment Videos

Last Updated: Jul 1, 2025

2D and 3D Matrices to Study Linear Invadosome Formation and Activity
12:25

2D and 3D Matrices to Study Linear Invadosome Formation and Activity

Published on: June 2, 2017

10.0K
Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification
09:11

Using Cell-substrate Impedance and Live Cell Imaging to Measure Real-time Changes in Cellular Adhesion and De-adhesion Induced by Matrix Modification

Published on: February 19, 2015

11.0K
Purification and Analysis of Caenorhabditis elegans Extracellular Vesicles
09:30

Purification and Analysis of Caenorhabditis elegans Extracellular Vesicles

Published on: March 31, 2020

7.6K

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • The extracellular matrix (ECM) regulates cellular functions and tissue properties through various signals.
  • Current synthetic biomaterials often separate polymer-based cues from cell-secreted factors.
  • Cells release nanoscale extracellular vesicles (EVs) that interact with the ECM.

Purpose of the Study:

  • To review extracellular vesicle-matrix interactions.
  • To explore how cells control EV biogenesis in response to ECM.
  • To discuss factors governing EV fate after secretion and their therapeutic potential.

Main Methods:

  • Literature review of extracellular vesicle-matrix interactions.
  • Analysis of cellular feedback mechanisms controlling EV biogenesis.
  • Examination of biomolecular and biophysical factors influencing EV localization.

Main Results:

  • EVs are integral components of the ECM, mediating cell-matrix communication.
  • Cellular processes, influenced by ECM, regulate EV production and release.
  • EV fate (retention, transport, uptake) is determined by complex interactions within the matrix.

Conclusions:

  • Understanding EV-matrix interactions is crucial for biomaterial design.
  • Engineered biomaterials can control EV release and retention for therapeutic applications.
  • Precise control over EV localization can elicit desired biological and therapeutic outcomes in host tissues.