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General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension

Bin Liu1,2,3, Dan Yi1,2,3, Xiaomei Xia1,2

  • 1Division of Pulmonary, Critical Care and Sleep, University of Arizona, Phoenix, Arizona, USA.

Biorxiv : the Preprint Server for Biology
|March 11, 2024
PubMed
Summary

In pulmonary arterial hypertension (PAH), lung capillary cells transform into arterial cells via the HIF-2a-Notch4 pathway. Targeting this transition offers a potential new treatment for PAH patients.

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