Canonical AREs are tumor suppressive regulatory elements in the prostate
Biorxiv : the Preprint Server for Biology
|March 11, 2024
Summary
Activating androgen response elements (AREs) can restore a growth-suppressive program in prostate cancer cells. This reactivation offers potential therapeutic benefits and is linked to better patient prognosis.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- The androgen receptor (AR) regulates prostate cell identity and differentiation, controlling normal gene expression.
- AR is hijacked in prostate cancer (PCa) to drive oncogenic transcription, but the regulatory elements involved are not fully understood.
Conclusions:
- Canonical AREs drive a normal, growth-suppressive, lineage-specific transcriptional program.
- This program can be re-engaged in PCa cells for potential therapeutic applications.
- ARE activity-driven gene signatures correlate with improved prognosis and luminal phenotypes in human PCa patients.
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