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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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Related Experiment Video

Updated: Jul 1, 2025

Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer
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Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of Response to Treatment in a Mouse Model of Lung Cancer

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A Lung Cancer Mouse Model Database.

Ling Cai, Ying Gao, Ralph J DeBerardinis

    Biorxiv : the Preprint Server for Biology
    |March 11, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Researchers created the Lung Cancer Mouse Model Database (LCMMDB) to centralize lung cancer preclinical data. This resource aids comparative analysis, improving mouse models for human lung cancer research.

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    Evaluation of Lung Metastasis in Mouse Mammary Tumor Models by Quantitative Real-time PCR
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    Area of Science:

    • Oncology
    • Bioinformatics
    • Genomics

    Background:

    • Lung cancer is the leading cause of cancer mortality, characterized by diverse subtypes and genetic complexity.
    • Preclinical mouse models are crucial for lung cancer research but suffer from data fragmentation.
    • A centralized, standardized resource is needed to integrate and compare data from various lung cancer mouse models.

    Conclusions:

    • The LCMMDB provides a powerful platform for cross-study comparisons of lung cancer mouse models.
    • This resource enhances the fidelity of the genetic landscape depicted in preclinical models.
    • The LCMMDB aims to bridge the gap between mouse models and human lung cancer, improving translational relevance.