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Dietary Magnesium Intake Is Inversely Associated With Ulcerative Colitis: A Case-Control Study
Omid Sadeghi1, Zeinab Khademi2, Parvane Saneei3,4
1Nutrition and Food Security Research Center, Department of Community Nutrition, Student Research Committee, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Crohn'S & Colitis 360
|March 11, 2024
Summary
Higher dietary magnesium intake may reduce the risk of developing ulcerative colitis (UC). This study found a significant inverse association between magnesium consumption and UC incidence in adults.
Area of Science:
- Gastroenterology
- Nutritional Science
- Epidemiology
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by gut inflammation and ulceration.
- Limited data exist on the association between dietary magnesium and UC.
- This study investigates the link between magnesium intake and UC in adults.
Purpose of the Study:
- To examine the relationship between dietary magnesium intake and the prevalence of ulcerative colitis.
- To determine if magnesium consumption is a protective factor against UC development.
Main Methods:
- A population-based case-control study involving 109 UC patients and 218 matched controls.
- Dietary intake assessed using a validated Food Frequency Questionnaire (FFQ).
- Data on potential confounders collected via a pretested questionnaire.
Main Results:
- Individuals with the highest magnesium intake (top tertile) showed a lower likelihood of having UC compared to those with the lowest intake (bottom tertile).
- A significant inverse association was observed between dietary magnesium and UC (crude OR: 0.32, 95% CI: 0.18-0.59).
- This inverse relationship persisted after adjusting for potential confounders (adjusted OR: 0.30, 95% CI: 0.14-0.68).
Conclusions:
- A diet rich in magnesium may play a role in preventing ulcerative colitis.
- Further research is warranted to validate these findings and elucidate the underlying mechanisms.
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