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Related Experiment Video

Updated: Jul 1, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

A case of immunotherapy-induced thyroiditis.

George Pears¹, Abhishek Mahajan^1,2, Anna Olsson-Brown³

¹Department of Imaging, The Clatterbridge Cancer Centre NHS Foundation Trust, L7 8YA Liverpool, UK.

Exploration of Targeted Anti-Tumor Therapy

|March 11, 2024

Summary

Cancer immunotherapy can cause thyroid problems, posing diagnostic challenges. Vigilance in serial imaging and clinical suspicion are key for diagnosing immunotherapy-induced thyroid dysfunction.

Keywords:

Immunotherapy cancer endocrinology melanoma radiology thyroiditis

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Area of Science:

Oncology
Endocrinology
Radiology

Background:

Cancer immunotherapy agents are increasingly used.
These treatments can lead to adverse thyroid events.
Diagnosing these events presents challenges for clinicians and radiologists.

Observation:

A 65-year-old male with malignant melanoma developed thyroid dysfunction and neck pain after starting immunotherapy.
Thyroid ultrasound revealed significant atrophy.
Review of prior imaging confirmed thyroiditis and subsequent atrophy.

Findings:

The patient was diagnosed with immunotherapy-induced thyroid dysfunction.
Thyroid function and symptoms improved after adjusting thyroxine and steroid doses.

Implications:

Highlights the importance of a high clinical index of suspicion for immunotherapy-induced thyroid dysfunction.
Emphasizes careful assessment of the thyroid on serial imaging studies.
Physicians and radiologists must remain vigilant in diagnosing and managing these adverse events.