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Updated: Jul 1, 2025

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance
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Targeted augmented reality-guided transperineal prostate biopsies study: initial experience.

Shenthiuiyan Theivendrampillai1, Bob Yang1, Mark Little1

  • 1Royal Berkshire Hospital, Reading, Berkshire, UK.

Therapeutic Advances in Urology
|March 11, 2024
PubMed
Summary
This summary is machine-generated.

This study shows that augmented reality (AR) guided prostate biopsies using Virtual Surgery Intelligence (VSI) Holomedicine are feasible for prostate cancer (CaP) diagnostics. The TARGET study demonstrated successful AR-guided biopsies, paving the way for future advancements.

Keywords:
HoloLensdiagnosticprostate cancertransperineal biopsyvirtual reality

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Area of Science:

  • Urology
  • Medical Imaging
  • Surgical Technology

Background:

  • Transperineal biopsy of MRI-detected prostate lesions is standard for prostate cancer diagnosis.
  • Virtual Surgery Intelligence (VSI) Holomedicine is a mixed reality (MR)/augmented reality (AR) platform for enhanced visualization.
  • This technology converts multiparametric prostate MRI into 3D holograms for image-assisted biopsy.

Purpose of the Study:

  • To investigate the feasibility of AR-guided prostate biopsies within an MR framework.
  • To evaluate the VSI Holomedicine platform for prostate cancer diagnostics.
  • To assess the TARGET study's approach to MR/AR-guided transperineal biopsies.

Main Methods:

  • Ten patients with suspected prostate cancer (PI-RADS 4/5) underwent AR-guided transperineal biopsy using VSI HoloLens.
  • The PrecisionPoint Freehand system was used for MR/AR-guided biopsies.
  • Cognitive fusion biopsies were performed as the standard of care post-procedure.

Main Results:

  • All 10 patients successfully completed the MR/AR-guided prostate biopsy procedure.
  • Prostatic tissue was successfully obtained in all MR/AR-guided specimens.
  • Histology matched in 70% of patients; no immediate complications were reported.

Conclusions:

  • The TARGET study demonstrates the viability of MR/AR-guided prostate biopsy using VSI Holomedicine for prostate cancer diagnostics.
  • This represents a potential advancement in minimally invasive prostate cancer detection.
  • Future research will focus on integrating real-time needle guidance and assessing diagnostic accuracy.