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Association of triglyceride-glucose index with vascular risk factors and clinical outcomes among COVID-19 patients: a
William Lumu1, Ronald Kasoma Mutebi1, Susan Nakireka1
1Department of Internal Medicine, Mengo Hospital, Kampala, Uganda.
The Pan African Medical Journal
|March 11, 2024
Summary
The triglyceride-glucose (TyG) index, a marker for insulin resistance, is linked to vascular risks and adverse outcomes in critically ill COVID-19 patients. A high TyG index indicates increased risk for severe illness and mortality.
Area of Science:
- Endocrinology
- Critical Care Medicine
- Cardiovascular Disease
Background:
- Insulin resistance is a key factor in metabolic disorders and cardiovascular disease.
- The triglyceride-glucose (TyG) index serves as a reliable indicator of insulin resistance.
- Critically ill COVID-19 patients often exhibit metabolic derangements that impact outcomes.
Purpose of the Study:
- To investigate the association between the triglyceride-glucose (TyG) index and vascular risk factors in critically ill adult COVID-19 patients.
- To determine the relationship between the TyG index and clinical outcomes in this patient population.
Main Methods:
- Retrospective analysis of 314 critically ill COVID-19 patients admitted to Mengo Hospital, Uganda.
- Calculation of TyG index using triglyceride and fasting glucose levels.
- Bivariate and multivariate logistic regression to assess associations with vascular risk factors and clinical outcomes.
Main Results:
- A high TyG index was prevalent in 85.4% of patients.
- The TyG index showed significant associations with elevated triglycerides, LDL cholesterol, total cholesterol, and glycated hemoglobin.
- A high TyG index was significantly associated with hospital death and a composite adverse outcome.
Conclusions:
- The triglyceride-glucose (TyG) index is a valuable marker for identifying vascular risk factors in critically ill COVID-19 patients.
- Elevated TyG index is associated with poorer clinical outcomes, including mortality, in this population.
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