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Updated: May 4, 2026
08:05
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
Published on: December 19, 2020
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Acro-Ischemia Associated With SARS-CoV-2: A Case Report
Jesus Ivan Martinez-Ortega1, Felipe de Jesus Perez Hernandez2, Angel Enrique Ortegon Blanco3
1Department of Dermatology, Instituto Dermatológico de Jalisco "Dr. José Barba Rubio", Zapopan, MEX.
Cureus
|March 11, 2024
Summary
A COVID-19 complication, acro-ischemic lesions (AIL), can be fatal despite anticoagulant therapy. This case highlights the need for novel treatments targeting inflammation and thrombosis in severe SARS-CoV-2 infections.
Area of Science:
- Infectious Diseases
- Vascular Medicine
- Dermatology
Background:
- Acro-ischemic lesions (AIL) are severe cutaneous manifestations of COVID-19, often linked to poor prognosis.
- Anticoagulant therapy is a standard treatment for AIL, with reported positive responses.
Observation:
- A 59-year-old male with severe COVID-19 developed acrocyanosis and hemiparesis.
- Despite anticoagulant therapy, the patient experienced worsening ischemia, leading to foot necrosis.
Findings:
- This case presents a fatal outcome of AIL in a COVID-19 patient despite standard anticoagulant treatment.
- Pathogenesis may involve SARS-CoV-2 interaction with ACE2 receptors, leading to vasculitis and immune clot formation.
Implications:
- Suggests exploring immunosuppressants alongside anticoagulants for AIL, drawing parallels with Behçet syndrome.
- Proposes novel therapeutic agents including N-acetyl cysteine, sulodexide, and hydroxychloroquine for severe COVID-19-associated AIL.
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