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  11. Acro-ischemia Associated With Sars-cov-2: A Case Report

Acro-Ischemia Associated With SARS-CoV-2: A Case Report

Jesus Ivan Martinez-Ortega1, Felipe de Jesus Perez Hernandez2, Angel Enrique Ortegon Blanco3

  • 1Department of Dermatology, Instituto Dermatológico de Jalisco "Dr. José Barba Rubio", Zapopan, MEX.

Cureus
|March 11, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

A COVID-19 complication, acro-ischemic lesions (AIL), can be fatal despite anticoagulant therapy. This case highlights the need for novel treatments targeting inflammation and thrombosis in severe SARS-CoV-2 infections.

Area of Science:

  • Infectious Diseases
  • Vascular Medicine
  • Dermatology

Background:

  • Acro-ischemic lesions (AIL) are severe cutaneous manifestations of COVID-19, often linked to poor prognosis.
  • Anticoagulant therapy is a standard treatment for AIL, with reported positive responses.

Observation:

  • A 59-year-old male with severe COVID-19 developed acrocyanosis and hemiparesis.
  • Despite anticoagulant therapy, the patient experienced worsening ischemia, leading to foot necrosis.

Findings:

  • This case presents a fatal outcome of AIL in a COVID-19 patient despite standard anticoagulant treatment.
  • Pathogenesis may involve SARS-CoV-2 interaction with ACE2 receptors, leading to vasculitis and immune clot formation.

Implications:

Keywords:
acroischemiaanticoagulationcovid 19sars-cov-2

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  • Suggests exploring immunosuppressants alongside anticoagulants for AIL, drawing parallels with Behçet syndrome.
  • Proposes novel therapeutic agents including N-acetyl cysteine, sulodexide, and hydroxychloroquine for severe COVID-19-associated AIL.
    • treatment option