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  11. Renal Protection By Ellagic Acid In A Rat Model Of Glycerol-induced Acute Kidney Injury

Renal protection by ellagic acid in a rat model of glycerol-induced acute kidney injury

Maryam Khombi Shooshtari1, Alireza Sarkaki2, Mohammad Rashno3,4

  • 1Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Veterinary Research Forum : an International Quarterly Journal
|March 11, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Ellagic acid protects against glycerol-induced kidney damage in rats by reducing inflammation. This study shows ellagic acid improves renal function and kidney tissue health in a rhabdomyolysis model.

Area of Science:

  • Nephrology
  • Toxicology
  • Pharmacology

Background:

  • Glycerol administration in animal models causes kidney damage via oxidative stress and inflammation.
  • Elevated blood urea nitrogen (BUN) and creatinine levels are key indicators of impaired renal function.
  • Rhabdomyolysis, a condition involving muscle breakdown, can lead to acute kidney injury.

Purpose of the Study:

  • To evaluate the protective effects of ellagic acid against glycerol-induced kidney damage in a rat model.
  • To investigate ellagic acid's impact on renal function biomarkers and inflammatory markers.
  • To assess the histopathological changes in kidney tissue following ellagic acid treatment.

Main Methods:

  • Sixty male Wistar rats were divided into control, glycerol-induced rhabdomyolysis, and three ellagic acid treatment groups.
Keywords:
Acute kidney injuryEllagic acidInflammationOxidative stress

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  • Rats received glycerol (8.00 mL/kg) to induce rhabdomyolysis, followed by varying doses of ellagic acid (25-100 mg/kg/day) for 14 days.
  • Serum levels of BUN, creatinine, lactate dehydrogenase, alkaline phosphatase, electrolytes, and inflammatory cytokines were measured. Kidney tissues were examined histopathologically.

    • Main Results:

    • Ellagic acid administration significantly improved renal function biomarkers compared to the rhabdomyolysis group.
    • Treatment with ellagic acid led to reduced levels of tumor necrosis factor-alpha and increased levels of interleukin-10.
    • Histopathological analysis revealed improvements in kidney tissue indices in rats treated with ellagic acid.

    Conclusions:

    • Ellagic acid demonstrates significant nephroprotective effects in a rat model of glycerol-induced kidney injury.
    • The protective mechanism of ellagic acid appears to involve the modulation of inflammatory processes.
    • Ellagic acid holds potential as a therapeutic agent for mitigating kidney damage associated with rhabdomyolysis.
    Rhabdomyolysis