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Candida albicans Biofilm Chip CaBChip for High-throughput Antifungal Drug Screening
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Published on: July 18, 2012

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Antifungal drug resistance in Candida: a special emphasis on amphotericin B

Lailema Ahmady1, Manisha Gothwal1, Muhammed Mushthaque Mukkoli1

  • 1Department of Biochemistry, School of Basic Sciences, Central University of Punjab, Bathinda, India.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|March 11, 2024
PubMed

Insights

Invasive fungal infections from Candida species are rising, especially in vulnerable patients. This review focuses on antifungal drug resistance in Candida, particularly Amphotericin B resistance mechanisms.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Invasive fungal infections caused by Candida species are increasing, particularly in immunocompromised and critically ill patients, leading to significant morbidity and mortality.
  • Factors contributing to the rise include aging populations, increased use of immunosuppressive medications, and prevalence of immunogenic diseases.
  • While Candida albicans is most common, non-albicans Candida species are also significant pathogens.

Purpose of the Study:

  • To review the current landscape of antifungal drug resistance in Candida species.
  • To specifically focus on the mechanisms of resistance to Amphotericin B (AmB).
  • To highlight the challenges in treating invasive fungal infections due to emerging resistance.

Main Methods:

  • Literature review of antifungal drug resistance in Candida species.
  • Focus on Amphotericin B (AmB) as a key antifungal agent.
  • Analysis of mechanisms underlying AmB resistance, including ergosterol alterations.

Main Results:

  • Candida species exhibit resistance to available antifungal drugs, complicating treatment.
  • Amphotericin B resistance is primarily linked to changes in fungal ergosterol content or structure.
  • Emerging resistance necessitates a deeper understanding of drug-fungus interactions.

Conclusions:

  • Antifungal drug resistance in Candida poses a significant clinical challenge.
  • Understanding resistance mechanisms, especially for Amphotericin B, is crucial for developing effective therapeutic strategies.
  • Continued research is needed to combat the growing threat of invasive fungal infections.
Keywords:
Candida speciesCandidiasisamphotericin Bantifungal drug resistanceergosterol

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