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Lessons learned from early-stage clinical trials for diabetic nephropathy
Marc Rendell1,2
1The Association of Diabetes Investigators, Newport Coast, CA, USA.
Expert Opinion on Investigational Drugs
|March 11, 2024
Summary
New diabetic nephropathy treatments, like SGLT2 inhibitors, evolve from basic science. Clinical trials reveal potential future therapies targeting cellular processes for improved kidney and heart health.
Area of Science:
- Nephrology
- Pharmacology
- Biochemistry
Background:
- Diabetic nephropathy treatment has advanced through understanding basic biochemistry and physiology.
- Current therapies, including SGLT2 inhibitors and mineralocorticoid blockers, offer benefits for both cardiac and renal disease.
Conclusions:
- Predicting the success of early-phase treatments is challenging.
- Observed benefits in both cardiac and renal function suggest primary subcellular effects.
- Future therapeutic development may focus on agents modifying fundamental cellular processes.
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