The relationship between long non-coding gene CASC21 polymorphisms and cervical cancer
Lili Han1, Jing Liu1, Mireayi Shataer1
1Department of Gynecology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumchi, Xinjiang, China.
Cancer Biology & Therapy
|March 11, 2024
Summary
Two genetic variations in the CASC21 gene, specifically rs16902094 and rs16902104, are linked to a higher risk of developing cervical cancer. This study provides new insights into CASC21
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- CASC21 is identified as a hotspot gene in cervical cancer.
- The association between CASC21 genetic polymorphisms and cervical cancer risk was previously unreported.
- Genetic factors are known to play a role in the development of cervical cancer.
Purpose of the Study:
- To investigate the correlation between CASC21 gene polymorphisms and the risk of cervical cancer.
- To identify specific CASC21 single nucleotide polymorphisms (SNPs) associated with cervical cancer susceptibility.
Main Methods:
- Case-control study involving 494 cervical cancer cases and 479 healthy controls.
- Genotyping of five CASC21 SNPs using the Agena MassARRAY platform.
- Statistical analyses included Chi-squared test, logistic regression, odds ratio (OR), multifactor dimensionality reduction (MDR), and 95% confidence intervals (95%CI).
Main Results:
- Two CASC21 SNPs, rs16902094 and rs16902104, showed a significant risk-increasing correlation with cervical cancer (p=0.014 for both).
- Stratification analysis confirmed the association of these SNPs with cervical cancer risk in specific subgroups (age > 51, BMI < 24 kg/m², smokers, squamous cell carcinoma).
- MDR analysis identified rs16902094 and rs16902104 as key contributing factors to cervical cancer risk.
Conclusions:
- This study is the first to establish a significant association between two CASC21 SNPs (rs16902094, rs16902104) and an increased risk of cervical cancer.
- These findings contribute to understanding the role of CASC21 in cervical carcinogenesis.
- The identified SNPs may serve as potential biomarkers for cervical cancer risk assessment.
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