Related Experiment Video
Updated: Jul 1, 2025
07:02
Assessment of Chemical Toxicity in Adult Drosophila Melanogaster
Published on: March 24, 2023
3.3K
The Clinical Toxicology Recommendations Collaborative: purpose, organization, and methodology
Martin F Wilks1,2, Christopher Hoyte3,4, Kirk L Cumpston5
1Swiss Centre for Applied Human Toxicology, University of Basel, Basel, Switzerland.
Clinical Toxicology (Philadelphia, Pa.)
|March 11, 2024
Summary
The Clinical Toxicology Recommendations Collaborative (CTRC) develops evidence-based guidelines for poisoning management. This collaborative approach aims to improve patient care through unified, expert recommendations.
Area of Science:
- Clinical Toxicology
- Medical Guidelines
- Evidence-Based Practice
Background:
- Scientific societies unify to address critical issues.
- The Clinical Toxicology Recommendations Collaborative (CTRC) was established in 2016.
- CTRC focuses on developing recommendations for unclear or controversial poisoning management.
Purpose of the Study:
- To establish evidence- and consensus-based recommendations for patient poisoning management.
- To create a unified stance on important issues in clinical toxicology.
- To foster positive change for poisoned patients through international collaboration.
Main Methods:
- Led by major clinical toxicology societies (AACT, APAMT, EAPCCT).
- Utilizes Institute of Medicine standards and AGREE instrument.
- Employs systematic reviews (GRADE methodology) and modified Delphi method (RAND/UCLA Appropriateness Method) for consensus.
- Recommendations approved by unanimous consent, detailing levels of evidence and strength of recommendations.
Main Results:
- The CTRC process involves systematic reviews and consensus-building.
- Recommendations are derived from rigorous evidence assessment and expert voting.
- Limitations include evidence quantity/quality and panel voting dynamics.
Conclusions:
- CTRC employs a transparent, evidence- and consensus-based approach.
- Aims to establish an international framework for clinical toxicology.
- Enhances education and decision-making for improved patient outcomes in poisoning cases.
Keywords:
Clinical Toxicology Recommendations CollaborativeClinical recommendationsDelphi methodLikert scaleSystematic reviewsMore Related Videos
Related Concept Videos
01:36Types of Toxins
1.7K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.7K
01:26Toxic Reactions: Overview
973
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
973
01:25Mutagenicity and Carcinogenicity
1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
01:28Preclinical Development: Overview
4.4K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.4K
01:25Drug Regulation
1.4K
Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...
1.4K
01:14Prevention of Further Absorption of Poison
821
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
821