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Improved Sleep Correlates with Improved Quality of Life and Motor Symptoms with Foslevodopa/Foscarbidopa
K Ray Chaudhuri1,2, Maurizio F Facheris3, Bruno Bergmans4,5
1Parkinson's Foundation International Centre of Excellence, King's College Hospital, London, UK.
Background:
Foslevodopa/foscarbidopa is a subcutaneous infusion of levodopa/carbidopa prodrugs.
Objectives:
Assess correlations between sleep and efficacy from interim data of a phase 3 trial of foslevodopa/foscarbidopa (NCT03781167).
Methods:
Pearson correlations between sleep (Parkinson's Disease Sleep Scale-2 [PDSS-2]) and quality of life (QoL; Parkinson's Disease Questionnaire-39), motor experiences of daily living (m-EDL; Movement Disorder Society-Unified Parkinson's Disease Scale Part II), and "Off"/"On" times were calculated for baseline and week 26 improvements. Regression analyses were adjusted for baseline PDSS-2 score.
Results:
Baseline sleep correlated moderately with QoL (r = 0.44, P < 0.001) and weakly with m-EDL (r = 0.28; P < 0.001). Sleep improvement weakly correlated with improved "Off" time (r = 0.37; P < 0.001) and QoL (r = 0.36; P < 0.001). Regression analyses demonstrated significant positive associations for improved sleep, "Off" time, QoL, and m-EDL.
Conclusions:
Improved sleep with foslevodopa/foscarbidopa was associated with improved QoL and "Off" time.
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