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Updated: Jul 1, 2025

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Published on: May 31, 2021
[Spontaneous remission of urticaria: does it exist and if so, when?]
Mathias Sulk1, Christoph M Hammers2, Guido Heine3
1Klinik für Hautkrankheiten, Universitätsklinikum Münster, Münster, Deutschland.
Background:
Urticaria mostly occurs acutely with a very high probability of spontaneous remission. When it persists for more than 6 weeks a chronic urticaria is manifest, which occurs either spontaneously or inducible by specific triggers. The underlying mechanisms are not fully understood but recent research points to defined pathogenetic factors.
Question And Aim:
Whether spontaneous remission is possible in urticaria is summarized descriptively in this review, and suggestions are given for the "step down" of urticaria treatment after remission. The mechanisms including autoallergic, immunoglobulin E (IgE)-dependent type I reactions and autoimmune, activating IgG-dependent type IIb reactions are presented. These are discussed in the context of spontaneous remission and the possibilities of induced remission.
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