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Related Experiment Video

Updated: Jul 1, 2025

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
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Relationships between obesity and functional outcome after ischemic stroke: a Mendelian randomization study.

Jieyi Lu1,2, Siqi Gong1,2, Juehua Zhu3

  • 1Department of Neurology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, China.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|March 11, 2024
PubMed
Summary
This summary is machine-generated.

Genetically predicted higher waist-to-hip ratio (WHR) is linked to worse functional outcomes after ischemic stroke. However, body mass index (BMI) showed no significant association, suggesting targeted obesity interventions may improve stroke recovery.

Keywords:
BMIMendelian randomizationObesityPost stroke outcomeWHRWHRadjBMI

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Area of Science:

  • Genetics
  • Neurology
  • Public Health

Background:

  • Obesity's impact on ischemic stroke outcomes is debated, with some studies suggesting a protective effect (obesity paradox).
  • Previous research indicates obesity may worsen functional outcomes post-stroke.
  • Genetic predisposition to obesity requires further investigation regarding stroke recovery.

Purpose of the Study:

  • To investigate the association between genetically predicted obesity and functional outcomes following ischemic stroke using Mendelian randomization (MR).
  • To differentiate the effects of body mass index (BMI) and waist-to-hip ratio (WHR) on post-stroke functional recovery.

Main Methods:

  • Utilized large-scale genetic data from UK Biobank and GIANT consortium for BMI and WHR instrumental variables.
  • Obtained functional outcome data from the Genetics of Ischemic Stroke Functional Outcome network.
  • Employed inverse-variance weighted (IVW) analysis as the primary method, with sensitivity analyses using alternative MR methods and heterogeneity assessments (I², Q statistics).

Main Results:

  • Univariable MR showed a significant association between genetic liability to WHR and worse functional outcome (mRS 3) after ischemic stroke (OR=1.47 [1.07, 2.02], P=0.016).
  • Genetic liability to BMI was not significantly associated with post-stroke functional outcome (P>0.05).
  • Multivariable MR analysis, adjusting for BMI, attenuated the association between WHR and functional outcome (OR=1.26 [0.76, 1.67], P=0.56).

Conclusions:

  • Genetic predisposition to a higher WHR, but not BMI, is correlated with unfavorable functional outcomes after ischemic stroke.
  • Findings suggest that interventions targeting central obesity (reflected by WHR) may be beneficial for improving stroke recovery.
  • Further research into the specific mechanisms linking WHR to stroke outcomes is warranted.