Identifying patients at risk for depression after radical cystectomy
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View abstract on PubMed
Summary
This summary is machine-generated.Depression is common in bladder cancer patients after radical cystectomy, often worsening post-surgery. Patients without prior depression are at higher risk, and recurrence is a key factor long-term.
Area Of Science
- Oncology
- Psychiatry
- Urology
Background
- Radical cystectomy for bladder cancer is a major surgery with significant physical and psychological impacts.
- Depression is a common comorbidity in cancer patients, potentially affecting treatment outcomes and quality of life.
Purpose Of The Study
- To assess the prevalence and progression of depressive symptoms in patients undergoing radical cystectomy for bladder cancer.
- To identify predictors of depression in this patient population.
Main Methods
- A cohort of 42 patients undergoing radical cystectomy were evaluated using the Beck Depression Inventory (BDI).
- Assessments were conducted preoperatively, on postoperative day 6, at six weeks, and 12-18 months post-surgery.
Main Results
- Prevalence of depressive symptoms (BDI score ≥10) increased from 36% preoperatively to 64% on postoperative day 6 and 69% at six weeks.
- Depression scores significantly increased postoperatively, peaking at six weeks. Patients without preoperative depression showed a greater increase.
- Disease recurrence was the most significant predictor of depression at 12-18 months post-surgery.
Conclusions
- Depression is highly prevalent and significantly progresses post-radical cystectomy for bladder cancer.
- Patients without pre-existing depressive symptoms are at increased risk for developing postoperative depression.
- Recurrence of bladder cancer is a major risk factor for long-term depression, necessitating targeted interventions.
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