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Tanshinone I Stimulates Pyroptosis of Cisplatin-Resistant Gastric Cancer Cells by Activating the

Guijun Wang1, Yanrong Li2, Zhaokai Guo1

  • 1Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

DNA and Cell Biology
|March 11, 2024
PubMed

Insights

Tanshinone I combats cisplatin resistance in gastric cancer by triggering pyroptosis, a programmed cell death pathway. This compound enhances the effectiveness of chemotherapy, offering a potential new strategy for gastric cancer treatment.

Area of Science:

  • Oncology
  • Pharmacology
  • Cell Biology

Background:

  • Cisplatin (DDP) resistance is a major challenge in gastric cancer (GC) treatment.
  • Tanshinone I, derived from *Salvia miltiorrhiza*, is a potential therapeutic agent.

Purpose of the Study:

  • To investigate the efficacy of Tanshinone I in overcoming DDP resistance in GC cells.
  • To elucidate the mechanisms underlying Tanshinone I's effects on DDP-resistant GC.

Main Methods:

  • Established DDP-resistant GC cell lines (BGC823/DDP, SGC7901/DDP) and a mouse xenograft model.
  • Assessed cell viability, proliferation, migration, ROS generation, and pyroptosis markers.
  • Utilized GSDME knockdown to confirm pathway involvement.

Main Results:

  • Tanshinone I inhibited proliferation and migration of DDP-resistant GC cells.
  • Tanshinone I increased intracellular ROS and activated pyroptosis via the NF-κB/caspase signaling pathway.
  • Combined DDP and Tanshinone I treatment suppressed tumor growth in vivo.

Conclusions:

  • Tanshinone I reverses DDP resistance in GC by inducing pyroptosis through the NF-κB/caspase-3(8)/GSDME pathway.
  • Tanshinone I represents a promising therapeutic agent for overcoming chemoresistance in gastric cancer.
Keywords:
Salvia miltiorrhizacell proliferationcisplatingastric cancerinflammationpyroptosis

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