Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

169
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
169
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

252
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
252
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

119
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
119
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

212
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
212
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

163
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
163
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can cervical spine axial GRE imaging replace FSE T2 axial imaging in the evaluation of central canal stenosis?

Neuroradiology·2026
Same author

Biodistribution and toxicity of inhaled nickel oxide nanoparticles: Potential application to realistic exposure.

Toxicology and applied pharmacology·2026
Same author

Metabolite-Based Endotypes of Asthma Reveal Distinct Clinical Characteristics and Immune Cell Signatures.

Allergy·2026
Same author

Integrated multiomics reveals starvation-driven keratin degradation and persistence in <i>Fervidobacterium islandicum</i> AW-1.

iScience·2026
Same author

Tryptophan-kynurenine metabolic reprogramming along the gut-brain axis alleviates Alzheimer's pathology.

Journal of neuroinflammation·2026
Same author

Photosynthetic and nutritional plasticity in mixotrophic dinoflagellates: responses to environmental change.

Frontiers in plant science·2026

Related Experiment Video

Updated: Jul 1, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.9K

Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway.

Jin-Ju Jeong1, Yoo-Jeong Jin2, Raja Ganesan1

  • 1Institute for Liver and Digestive Disease, College of Medicine, Hallym University, Chuncheon, Korea.

Probiotics and Antimicrobial Proteins
|March 12, 2024
PubMed
Summary

Multistrain probiotics, Sensi-Biome, effectively controlled diarrhea in rats by modulating gut microbiota and metabolites. This intervention positively impacted the microbiome-neuron axis, improving gut health and reducing inflammation.

Keywords:
Acetic acidCytokinesDiarrheaMetabolitesMicrobiomeMultistrain probiotics

More Related Videos

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
08:53

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

830
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.6K

Related Experiment Videos

Last Updated: Jul 1, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.9K
Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
08:53

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

830
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
07:15

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

9.6K

Area of Science:

  • Gastroenterology and Microbiology
  • Gut Microbiome Research
  • Neurogastroenterology

Background:

  • Diarrhea is a common symptom linked to gut dysbiosis.
  • The microbiome-neuron axis plays a crucial role in gut health.
  • Understanding probiotic effects on diarrhea requires investigating this axis.

Purpose of the Study:

  • To evaluate the efficacy of a multistrain probiotic (Sensi-Biome) in managing diarrhea.
  • To explore the impact of Sensi-Biome on the gut microbiome-neuron axis.
  • To analyze the effects on diarrhea-related parameters, inflammation, and gut metabolites.

Main Methods:

  • A rat model of diarrhea induced by 4% acetic acid.
  • Administration of Sensi-Biome at varying concentrations (1x10^8 to 1x10^10 CFU/0.5 mL).
  • Analysis of stool parameters, inflammatory cytokines, gut microbiota (16S rRNA), and cecal metabolomics (LC-Orbitrap MS).

Main Results:

  • Significant recovery of stool moisture, intestinal movement rate, and pH in the highest probiotic dose group (G3).
  • Modulation of serotonin levels and tryptophan hydroxylase expression, indicating improved microbiome-neuron axis function.
  • Increased relative abundance of Firmicutes, altered short-chain fatty acids, and improved levels of equol and oleamide.

Conclusions:

  • Sensi-Biome demonstrates significant efficacy in controlling diarrhea.
  • The probiotic's action involves modulating gut metabolites and the serotonin pathway.
  • These findings highlight Sensi-Biome's potential for managing diarrhea via the microbiome-neuron axis.