Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

2.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.0K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

7.4K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
7.4K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

781
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
781
Regulation of Metabolism01:19

Regulation of Metabolism

9.4K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.4K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

908
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
908
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chk1 inhibition emerges as the most effective partner for PARP inhibition in BRCA-proficient pancreatic cancer.

Discover oncology·2026
Same author

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.

Science (New York, N.Y.)·2026
Same author

A peripheral neurons-basophil axis drives heat-killed Staphylococcus aureus-induced dermatitis through toll-like receptor 2 signaling pathway.

The Journal of investigative dermatology·2026
Same author

Regnase-1-mediated regulation of neutrophils modulates SARS-CoV-2 pneumonia.

PLoS pathogens·2026
Same author

Anti-Integrin αvβ6 Autoantibodies Predict Response and Treatment Persistence to Advanced Therapies in Ulcerative Colitis.

Clinical and translational gastroenterology·2026
Same author

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis.

Frontiers in immunology·2026

Related Experiment Video

Updated: Jul 1, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

264

RNA Metabolism Governs Immune Function and Response.

Masanori Yoshinaga1, Osamu Takeuchi2

  • 1Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Advances in Experimental Medicine and Biology
|March 12, 2024
PubMed
Summary

Post-transcriptional regulation by RNA-binding proteins (RBPs) is crucial for controlling inflammation. These proteins fine-tune immune gene expression, preventing detrimental inflammatory and autoimmune diseases.

Keywords:
Immune cell developmentInflammatory responsePost-transcriptional regulationProinflammatory cytokinesRNA methylationRNA-binding proteins

More Related Videos

Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

6.9K
Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

408

Related Experiment Videos

Last Updated: Jul 1, 2025

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

264
Analysis of Human Natural Killer Cell Metabolism
09:03

Analysis of Human Natural Killer Cell Metabolism

Published on: June 22, 2020

6.9K
Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

408

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Inflammation is a vital immune response but can be harmful if dysregulated.
  • Aberrant inflammation is linked to various autoimmune diseases.
  • Post-transcriptional regulation is key to controlling immune gene expression.

Approach:

  • This review examines the role of RNA metabolism in immune regulation.
  • Focuses on RNA-binding proteins (RBPs) like Regnase, Roquin, and RNA methyltransferases.
  • Highlights their function in mRNA decay and translation control.

Key Points:

  • RBPs, including Regnase and Roquin, precisely control immune gene expression.
  • These proteins regulate mRNA decay and translation of key inflammatory mediators like TNF and IL-6.
  • Their coordinated action prevents excessive immune activation.

Conclusions:

  • Understanding RBP function is critical for developing therapies for inflammatory and autoimmune diseases.
  • Post-transcriptional control mechanisms are essential for maintaining immune homeostasis.
  • Further research into RBP networks will illuminate disease pathogenesis.