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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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HLA Genetics for the Human Diseases.

Takashi Shiina1, Jerzy K Kulski2,3

  • 1Tokai University School of Medicine, Isehara, Japan. tshiina@is.icc.u-tokai.ac.jp.

Advances in Experimental Medicine and Biology
|March 12, 2024
PubMed
Summary
This summary is machine-generated.

Human leukocyte antigen (HLA) genes are highly polymorphic and crucial for immune responses and disease pathogenesis. Over 35,000 HLA alleles are known, with many linked to over 100 diseases.

Keywords:
AlleleDisease associationGene expressionHaplotypeHuman leukocyte antigenMajor histocompatibility complexNext generation sequencingPolymorphismTransposable element

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Area of Science:

  • Immunogenetics
  • Human Leukocyte Antigen (HLA) complex
  • Genomic Medicine

Background:

  • Human leukocyte antigen (HLA) molecules are highly polymorphic and essential for immune regulation, transplant compatibility, and disease susceptibility.
  • Over 35,000 HLA alleles are cataloged, with specific alleles and haplotypes associated with more than 100 diseases and phenotypes.
  • The HLA region's genetic complexity contributes to its significant role in health and disease.

Conclusions:

  • Understanding HLA genomic structure and polymorphism is vital for comprehending immune function and disease.
  • The genetic landscape of the HLA region harbors numerous disease associations.
  • Continued research, aided by technologies like NGS, will further elucidate HLA's role in health and disease.