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Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
Published on: July 16, 2013
Dissolution of presumed calcareous corneal degeneration with 13.8% ethylenediaminetetraacetic acid solution in 17
Richard A Pytak1, Neal T Wasserman1
1Eye Care for Animals-Wheeling, Wheeling, Illinois, USA.
Purpose:
To describe a novel treatment for dissolving calcareous corneal degeneration (CCD)-associated mineral in 17 dogs with 13.8% ethylenediaminetetraacetic acid (EDTA) solution.
Methods:
Cases seen between 2021 and 2023 were reviewed. Seventeen dogs with CCD associated with corneal ulcerations were treated with a mineral dissolution procedure using 13.8% EDTA solution. A diamond burr keratotomy (DBK) was subsequently performed in some cases when residual mineralization remained present.
Results:
Of the 19 eyes (17 dogs) included in the study, 10 eyes (8 dogs) required a DBK procedure. One eye (one dog) required a repeat procedure 26 weeks following the initial procedure and two eyes (one dog) required a repeat procedure 24 and 37 weeks following initial treatment in the left and right eye, respectively. Mean follow-up time to last recheck for eyes not requiring a second chelation procedure was 20.4 weeks (range, 10-47 weeks). At the last follow-up examination for all 17 dogs, the CCD resolved in 26.3%, improved in 57.9%, and recurred in 15.8% of eyes. Complications occurred in two eyes (two dogs) and included an infected stromal ulcer at 2-week recheck and the creation of a 40% depth stromal defect immediately following debridement. Both complications were successfully addressed with medical management.
Conclusions:
The utilization of 13.8% EDTA solution appears to be an effective and safe means of treating lesions associated with CCD.
