Comparative analysis of perioperative and long-term outcomes of patients with hepatocellular carcinoma: Nonalcoholic fatty liver disease versus viral hepatitis
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View abstract on PubMed
Summary
This summary is machine-generated.Outcomes for non-alcoholic fatty liver disease (NAFLD)-related liver cancer (HCC) surgery are similar to viral-related HCC. Early detection and surgery in NAFLD-HCC patients may improve prognosis.
Area Of Science
- Hepatology
- Surgical Oncology
- Gastroenterology
Background
- Nonalcoholic fatty liver disease (NAFLD)-related hepatocellular carcinoma (HCC) presents distinct oncological characteristics compared to viral-related HCC.
- Short- and long-term outcomes of surgical resection for NAFLD-related HCC are not well-defined, with conflicting reports on postoperative survival and complications.
Purpose Of The Study
- To compare the clinical, surgical, pathological, and survival outcomes of hepatectomy for NAFLD-related HCC versus virus-related HCC.
Main Methods
- Retrospective analysis of 1047 patients who underwent hepatectomy for HCC.
- Comparison of 57 patients with NAFLD-related HCC (NAFLD group) and 727 with virus-related HCC (VH group).
- Evaluation of clinical, surgical, pathological, and survival data.
Main Results
- NAFLD group had higher BMI and HbA1c. Tumor size was larger in the NAFLD group.
- Operative time, bleeding, morbidity, and hospital stay were similar between groups.
- No significant differences in overall or recurrence-free survival were observed initially, but subgroup analysis showed better prognosis for NAFLD-HCC with matched tumor diameters.
Conclusions
- Hepatectomy outcomes are comparable between NAFLD-related HCC and virus-related HCC.
- Early detection and surgical intervention in NAFLD-HCC may enhance patient prognosis.
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